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If you're using handcuffs, make sure they are real, police-quality handcuffs, not the shitty ones sold in novelty stores. There are a couple good ways to know if you're using real cuffs or not. Real cuffs have two links between the cuffs; fake ones have three. Also, real cuffs have a simple-looking key that ends in a single loop with a short pin extending from it; fake cuffs usually have a 'gothic' looking key, with three loops on the end. Fake cuffs break easily, often have burrs and rough edges, can't be double-locked to prevent tightening, and simply aren't safe for use. Police-quality cuffs only cost $20-30, and can be ordered online, found in army surplus stores and uniform sales stores, and the like, so don't do handcuff bondage without them. And always double-lock the cuffs so they don't tighten and injure the sub.
How long a sub can stay in a bondage position varies depending on the position; spread-eagle is very easy on the body, and I've heard of subs sleeping in some hogties. But most bondage positions place stress on some joints and many restrict blood flow. Positions like that can't be safely maintained for more than 15-30 minutes (depending on the sub and the position). Probably the safest position would be some variation on what you often seen in movies--the sub has one wrist cuffed, and the other end of the cuff is locked to a radiator or pipe. A position like that allows the sub to move his or her whole body and enables them to avoid cramping.
Having said that, thought, keeping a sub handcuffed to a radiator for a whole weekend is a bad idea. The sub won't be able to use a toilet and will have to soil themselves, which will completely ruin the erotic edge of the scene. They won't sleep very well either. And, as Smallest notes, they will be unable to get away if a fire breaks out, they have a medical emergency, or something similar. What might work a little better would be to chain them to a radiator with a very long length of chain, and make sure that the key is accessible if an ER happens.
But long-term confinement is not very interesting or erotic for the sub. I've talked to subs who've done it (weekend in a cage, for example) and they generally say that after an hour or two they just got bored. So while this might be your fantasy, it probably won't be much fun for you sub.
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